Sign Out
Pharmacology: Carbocisteine normalizes the viscosity (thickness) of secretions in the respiratory tract in several possible ways. It may act on the mucus-producing cells, modifying their internal processes so that they secrete mucus that is "thin" and less adhesive. If thick phlegm is already formed, Carbocisteine may act on it by alternating its physicochemical properties. This results in loosening of the mucus fibers of the thick secretion to facilitate its elimination by the cough mechanism.
Pharmacokinetics: Carbocisteine is rapidly and well absorbed after oral administration. Following oral administration of 1.5g Carbocisteine, peak serum concentrations of 13-16 mg/L were reached in 1-2 hours. Plasma half-life was 1.5 to 2 hours. Carbocisteine penetrates well into lung tissues and respiratory mucus, suggesting local action. Carbocisteine undergoes acetylation, decarboxylation, and sulfoxidation. Majority of the drug is excreted unchanged in the urine.
